Journal of Cancer Research and Practice

CASE REPORT
Year
: 2022  |  Volume : 9  |  Issue : 1  |  Page : 41--44

Long-term remission by nivolumab monotherapy for sorafenib-refractory hepatocellular carcinoma


Chia-Yu Chen, Li-Yuan Bai 
 Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan

Correspondence Address:
Prof. Li-Yuan Bai
Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, China Medical University, No. 2, Yude Rd., North Dist., Taichung City 404332
Taiwan

Hepatocellular carcinoma (HCC) is considered to be a relatively chemotherapy-resistant tumor. There was no standard systemic therapy for patients with metastatic HCC until 2007 when sorafenib was demonstrated to be superior to supportive care. Lenvatinib has also been used as a first-line choice since a randomized phase III noninferiority trial was conducted in 2018. In the second-line setting, regorafenib was the first drug to be approved for sorafenib-refractory advanced HCC. Other drugs such as cabozantinib and ramucirumab have also shown benefits in a second-line setting. Immunotherapy is another novel and well-tolerated treatment option for patients who are refractory to tyrosine kinase inhibitors. Here, we present a patient with HCC which progressed after sorafenib treatment, and who subsequently achieved a nearly complete remission after nivolumab monotherapy. Maintenance therapy with nivolumab every 2–3 months was prescribed to sustain the good response based on a previous study that used rituximab maintenance therapy in a patient with follicular lymphoma.


How to cite this article:
Chen CY, Bai LY. Long-term remission by nivolumab monotherapy for sorafenib-refractory hepatocellular carcinoma.J Cancer Res Pract 2022;9:41-44


How to cite this URL:
Chen CY, Bai LY. Long-term remission by nivolumab monotherapy for sorafenib-refractory hepatocellular carcinoma. J Cancer Res Pract [serial online] 2022 [cited 2022 Jun 30 ];9:41-44
Available from: https://www.ejcrp.org/article.asp?issn=2311-3006;year=2022;volume=9;issue=1;spage=41;epage=44;aulast=Chen;type=0