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CASE REPORT
Year : 2022  |  Volume : 9  |  Issue : 3  |  Page : 101-103

Poorly differentiated neuroendocrinecarcinoma of the gallbladder

Chen-Hao Chang1, Jiunn-Chang Lin2, Johnson Lin3, Ching-Wei Chang4
1 Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital; MacKay Medicine, Nursing and Management College, Taipei, Taiwan
2 MacKay Medicine, Nursing and Management College; Department of Surgery, MacKay Memorial Hospital, Taipei, Taiwan
3 MacKay Medicine, Nursing and Management College; Division of Hematology-Oncology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei; MacKay Medical College, New Taipei, Taiwan
4 Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital; MacKay Medicine, Nursing and Management College, Taipei; MacKay Medical College, New Taipei, Taiwan

Correspondence Address:
Dr. Ching-Wei Chang
Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, No. 92, Sec. 2, Chungshan North Road, Taipei 104
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_4_22

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Poorly differentiated neuroendocrine carcinoma of the gallbladder is an aggressive and extremely rare type of neuroendocrine tumor. The clinical presentations in most cases are nonspecific, resulting in patients being diagnosed at an advanced stage of the disease. Herein, we report our experience with the case of a 63-year-old woman with no comorbidities who underwent radical resection for a diagnosed gallbladder mass. Abdominal computed tomography scans and magnetic resonance cholangiopancreatography indicated intraluminal masses in the gallbladder with liver invasion. Histologically, the mass was composed of solid sheets of poorly differentiated carcinoma cells with hyperchromatic nuclei; a high Ki-67 index of approximately 80%. The cells were positive for chromogranin A and synaptophysin, and small-cell-type neuroendocrine carcinoma was diagnosed. Postoperatively, she underwent adjuvant chemotherapy with four cycles of cisplatin/etoposide chemotherapy and was disease-free 16 months after surgical treatment with normal hormone-specific markers.


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