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CASE REPORT
Year : 2021  |  Volume : 8  |  Issue : 4  |  Page : 152-158

Durable response of immune checkpoint inhibitor after failure of gemcitabine-based chemotherapy for a patient with metastatic biliary tract cancer


1 Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
2 Department of Oncology, National Taiwan University Hospital; Graduate Institutes of Oncology, National Taiwan University College of Medicine; Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan

Correspondence Address:
Dr. Chiun Hsu
Department of Medical Oncology, National Taiwan University Cancer Center, No. 57, Ln. 155, Sec. 3, Keelung Rd., Da'an Dist., Taipei City 106
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_22_21

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Patients with advanced or metastatic biliary tract cancer (BTC) have poor survival and limited options of systemic anticancer therapy besides the combination of gemcitabine plus cisplatin. Recent advances in molecular screening have identified that a minor proportion of BTC patients may benefit from specific targeted agents, e.g., fibroblast growth factor receptor or isocitrate dehydrogenase 1 inhibitors. The role of immune checkpoint inhibitor therapy in advanced BTC remains unclear. In this report, we describe a patient with intrahepatic cholangiocarcinoma who suffered from rapid progression of extrahepatic metastases after surgery and progression of the tumors after chemotherapy. Pembrolizumab was given, and the patient remained in partial response at the time of writing this report, after 1½ years of pembrolizumab therapy, without evident adverse events. We also review and discuss the current landscape of systemic therapy for advanced BTC and the possible role of immune checkpoint inhibitor therapy.


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