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REVIEW ARTICLE
Year : 2021  |  Volume : 8  |  Issue : 4  |  Page : 127-133

Success is not final, failure is not fatal: The changing landscape of systemic therapy for advanced hepatocellular carcinoma


Graduate Institute of Oncology, National Taiwan University College of Medicine; Department of Medical Oncology, National Taiwan University Cancer Center; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan

Correspondence Address:
Dr. Chiun Hsu
Department of Medical Oncology, National Taiwan University Cancer Center, No. 57, Ln. 155, Sec. 3, Keelung Road, Da'an District, Taipei City 106
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_21_21

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Objective: To review the history of development of systemic therapy for advanced hepatocellular carcinoma (HCC). Data Sources: Published clinical trials of single-agent targeted agents, single-agent immune checkpoint inhibitors (ICI), and ICI-based combination regimens. Results: Key lessons learned from previous positive and negative clinical trials included design of more efficient clinical trials and incorporation of trial endpoints most relevant to clinical benefit. Major challenges included prioritization of novel combination therapies for clinical trials and development of predictive biomarkers. Conclusion: The improved efficacy and safety of systemic therapy will impact on future multi-disciplinary management of HCC through more extensive integration with liver-directed therapy for different stages of HCC patients.


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