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Year : 2020  |  Volume : 7  |  Issue : 3  |  Page : 99-104

Immuno-potentiating effects of Astragalus polysaccharides: A mini-literature review

1 Department of Hematology and Oncology, Shin-Kong Wu Ho.Su Memorial Hospital, Taipei, Taiwan
2 Department of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan

Correspondence Address:
Dr. Jo- Pai Chen
Department of Oncology, National Taiwan University Hospital, Yun-Lin Branch, No. 95, Xuefu Rd., Huwei Township, Yunlin 632
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCRP.JCRP_3_20

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Objective: Astragalus polysaccharides (APS) is a promising therapeutic agent because of its long history in ethnopharmacology, extensive research, wide application, and few side effects. Among its diversified properties, APS has been widely investigated for its immuno-potentiating effects such as stimulating T- and B-cell proliferation, regulating the expression of cytokines, activating macrophages, inducing the expression of surface antigens on lymphocytes, and promoting the production of antibodies. Data Sources: In this article, we review the research progress of APS focusing on its immuno-potentiating effects. Results: Based on the existing studies, APS appears to be a promising adjuvant to anticancer therapy, vaccines, antibiotics, and antiviral therapy. The information provided in this mini-review will provide a useful quick reference for its rational clinical utilization and in planning further research. Further studies are needed to evaluate its dose optimization, mechanism of action, and therapeutic combination strategies. Conclusion: APS may be another successful example of the standardization and modernization of Traditional Chinese herbal medicine.

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