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Year : 2020  |  Volume : 7  |  Issue : 1  |  Page : 1-10

Clinical application of 18F-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography for cancer cells in lung cancer

1 Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Pharmacology, School of Medicine, Yasouj University of Medical Sciences, Yasouj, Iran
3 Department of Biology, School of Basic Sciences, Yasouj University, Yasouj, Iran

Correspondence Address:
Seyyed Hossein Hassanpour
Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCRP.JCRP_16_19

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Purpose: One of the most important tools used in the diagnosis and treatment of lung cancer in patients with or suspected of having lung cancer is positron emission tomography-computed tomography XS(PET-CT). The popularity of this method is rapidly increasing. Material and Review Method: We searched papers on the topic of the recognition of cancer cells in lung cancer using18F-fluoro-2-deoxy-D-glucose (FDG) PET-CT using keywords such as18F-FDG PET-CT and lung cancer, 18F-FDG PET-CT imaging in oncology, cancer and nuclear medicine, diagnosis of lung cancer and imaging, molecular imaging in cancer, false-positive18F-FDG PET-CT scans and oncology, application of18F-FDG PET-CT in staging and metabolic activity assessment of cancer, and PET-CT imaging method. Results: In this review, we found the following results: 1.Due to the high diagnostic sensitivity of PET-CT scans, it is possible to reject malignancy in pulmonary cells using this method 2. PET-CT scans decrease the number of unnecessary procedures. 3. According to the findings of this review study, high sensitivity in PET-CT is the major advantage compared to other methods used to rule out the possibility of malignancy of lung cells; it is necessary but not sufficient. Conclusions: Regarding the imaging of abnormal pulmonary cells using PET-CT, except for a few exceptions, if the result of a PET-CT scan is negative, these abnormalities can confidently be considered to be benign. These exceptions include nonsolid and small (<1 cm) pulmonary nodules. Until all metastases in the pulmonary cells are imaged and detected by PET-CT, no drug regimen should be started. Finally, lymph node tumor metastasis cannot be ruled out solely based on a negative result of PET-CT imaging with these abnormalities, and to confirm it, aggressive staging should be performed in most patients before mediastinal metastasis is confirmed or rejected.

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